Genetic variants in STAT4 linked to disabling pansclerotic morphea: JAK inhibition shows promise

Genetic variants in STAT4 linked to disabling pansclerotic morphea: JAK inhibition shows promise

Hratch Baghdassarian, graduate, PhD candidate Credit: Google Scholar A collaborative effort involving 14 institutions sought to examine genetic variants in STAT4 that correlate with disabling pansclerotic morphea (PMD), a rare systemic inflammatory disease. The study results revealed the therapeutic potential of Janus kinase (JAK) inhibition. The investigators observed that gain-of-function variants in STAT4 were associated … Read more